Scurvy

-Alec Rezigh

❓What❓

• A multisystem disease of collagen fragility, deranged vasoreactivity, & inflammation that results from deficiency of vitamin C

❓Epidemiology❓

• Diet poor in fruits & vegetables

• Distal ileum disease
• Cystic fibrosis
• Celiac disease
• Bariatric surgery

❓Presentation❓

↓ Collagen Cross-Linking

Deranged Vasoreactivity

• Pulmonary hypertension (↓ nitric oxide)

• Orthostatic hypotension (↓ catecholamines)

Inflammation

• ↑ ESR, ↑ CRP

❓Diagnosis❓

• Visualization of corkscrew hairs ⊕ perifollicular hemorrhage

• [Vitamin C] measurement < 0.2 mg/dL

❓Treatment❓

• Supplement!

📚 References 📚

• Scurvy: Rediscovering a Forgotten Disease

• Rheumatic manifestations of scurvy: a report of three recent cases in a major urban center and a review

• Scurvy Can Be Mistaken for Rheumatologic Disorders

• Vitamin C Deficiency

• A Fruitful Workup (NEJM CPS)

• LibreTexts (Vitamin C)

Socials

@Dx_Atypia

@ASanchez_PS

@mikearcieri.bsky.social

Contact

Dx.atypia@gmail.com